Researchers have discovered that a burgeoning deer population forever alters the progression of a forest's natural future by creating environmental havoc in the soil and disrupting the soil's natural seed banks.
Not only are neuropathic pain symptoms quite common in knee osteoarthritis, but scientists can predict who will respond to treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) by assessing the nervous system’s own capacity to regulate pain, new research suggests. Patients whose tests had indicated superior conditioned pain modulation (CPM) had less pain and fewer neuropathic symptoms.
Of nearly 1 million veterans who receive opioids to treat painful conditions, more than half continue to consume opioids chronically or beyond 90 days, new research says. A number of factors were associated with opioid discontinuation with the goal of understanding how abuse problems take hold in returning veterans.
Most patients with multiple defects of the cytochrome P450 system, which is largely responsible for metabolizing opioids, naturally gravitated toward an opioid regimen primarily metabolized through the cytochrome P450 3A4 enzyme or a non-cytochrome, metabolic pathway, a new study suggests.
Two hormones credited with reducing pain and need for opioid analgesics when released naturally during pregnancy and childbirth worked similarly when administered simultaneously to patients with intractable pain, research shows.
Researchers have debated for more than two decades the likely impacts, if any, of global warming on the worldwide incidence of malaria, a mosquito-borne disease that infects more than 300 million people each year.
Our DNA and its architecture are duplicated every time our cells divide. Histone proteins are key building blocks of this architecture and contain crucial information that regulates our genes. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent disease. The results are published in the journal Nature Communications.
This shows the North Atlantic tracking routes of 17 juvenile loggerhead sea turtles. A new study satellite tracked 17 young loggerhead turtles in the Atlantic Ocean to better understand sea turtle nursery grounds and early habitat use during the 'lost years.' The study, conducted by a collaborative research team, including scientists from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, was the first long-term satellite tracking study of young turtles at sea.
Papilio polytes, an Asian swallowtail butterfly species also known as the Common Mormon, possesses distinctive mimicry patterns (left). The same species also has non-mimetic forms (right). A single gene regulates the complex wing patterns, colors and structures required for mimicry in swallowtail butterflies, report scientists from the University of Chicago, March 5 in Nature. Surprisingly, the gene described, doublesex, is already well-known for its critical role in sexual differentiation in insects.
Lentiviruses, which belong to the family of retroviruses, are used as vectors to exchange genetic material in cells and can be used to replace a defective gene as defined by gene therapy. Increasing the efficiency of such a treatment poses a major medical challenge: the virus should specifically track the target cells, but the number of virus used should be as low as possible.